Alexis Nolfi, bioengineering graduate student in the Swanson School of Engineering at the University of Pittsburgh and an ARCS Scholar Alum, is recognized by the Carnegie Science Awards
Nolfi is involved in numerous projects centered on how the immune system is involved in the pathogenesis of disease and how we can modify immune response to biomaterials and with biomaterials-based approaches. Much of her work has a distinct focus in women’s health applications, including a polypropylene mesh often used in pelvic surgery and a novel ovarian hydrogel that could one day be used to generate a tissue-appropriate model of endometriosis.
According to Nolfi, the field of basic science research in women’s health topics is underserved by the biomaterials and regenerative medicine community. She believes that this research helps to shine light on topics deserving of more attention, and the experimental findings and developments will be applicable to not only biomaterials-based urogynecologic applications, but also to furthering advancement of other biomaterial and immunology-based fields.
As part of her work with biomaterials, she and the lab developed a novel contact lens that is coated with an immune modifying molecule for the treatment of dry eye disease. The bioengineering- and opthamology-led research group was recently awarded $100,000 at the 2019 Pitt Innovation Challenge.